Myoepithelial cells in these cases constitute the basal cell layer of an epithelium that harbors the epithelial progenitor. Myoepithelioma is a benign salivary gland tumor in the head and neck region, accounting for 11. K5k14positive cells contribute to salivary glandlike. Myoepithelioma is a rare benign tumor of the salivary glands and is usually seen in the parotid gland and the minor salivary glands. Myoepithelial cells are normal components of salivary glands, sweat glands and breast. This tumor is usually located in the parotid gland and the minor salivary glands of the soft palate and represents less than 1% of all salivary gland tumors. Original article, clinical report by ear, nose and throat journal. However, they may be malignant and infiltrate locally. Combined myoepithelial carcinoma and myoepithelioma in. Salivary gland myoepithelial carcinoma mc or malignant myoepithelioma is a rare entity. Vimentin and s100 protein are very sensitive but nonspecific immunohistochemical markers of neoplastic myoepithelium. Myoepitheliomas are rare, benign neoplasms affecting predominantly parotid gland and to a lesser extent minor salivary glands. The lesions were clinically suspected to be epidermal cyst. Myoepitheliomas usually occur in the major salivary glands and appear in the subcutis of the ventral neck.
They most commonly affect the major and minor salivary glands with the parotid gland being the most common, approximately 40%. The topic malignant myoepithelioma of salivary gland you are seeking is a synonym, or alternative name, or is closely related to the medical condition myoepithelial carcinoma of salivary gland. Immunohistochemical evaluation of 25 salivary gland basal cell and canalicular adenomas. Benign myoepithelioma of the lung a case report and. Pdf salivary gland myoepithelial carcinoma mc or malignant myoepithelioma is a rare entity. We selected 4 cases of small salivary gland myoepitheliomas from the files of the pathology lab of the oral pathology department of the federal university of. Hence, histopathologic examination should be considered to differentiate these tumors. It has a relatively poor clarification of its biologic behavior, clinicopathologic features and immunohistochemical profile. Nov 18, 2016 myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues.
Myoepithelioma was recognized as a histologically distinct entity by the world health organization who in 1991. Myoepithelioma of minor salivary gland of cheek cytology description nuclear grooves, intranuclear cytoplasmic inclusions, nuclear striations zebra lines, myxoid matrix. Pdf spindle cell myoepithelioma of the parotid gland. Salivary gland basal cell and canalicular adenomas archives.
The initial tumour was a pleomorphic adenoma with epithelial and myoepithelial elements. Dec 12, 2011 myoepithelioma is a rare benign tumor of the salivary glands and is usually seen in the parotid gland and the minor salivary glands. Histologically, two distinct neoplastic cell populations were observed in the same tumor mass. Treatment should be designed as for a benign salivary gland tumor with a margin of normal uninvolved tissue being included within the surgical excision. Myoepithelioma of a minor salivary gland of the cheek. Review and updates of immunohistochemistry in selected. Most studies have found that 75% of myoepithelial carcinomas arise in the major salivary glands and that about half arise in precursor lesions. Get a printable copy pdf file of the complete article 1. We report two patients with myoepithelioma of parotid gland presenting as infraauricular subcutaneous mass. Pdf salivary gland myoepithelial carcinoma researchgate. Salivary gland myoepithelial carcinoma springerlink.
Myoepithelioma is usually a benign tumor arising from neoplastic myoepithelial or basket cells which are found between the basement membrane and the. Variability in cellular morphology and stromal composition leads to diagnostic pitfalls on fine. The histological appearance includes solid, myxoid and reticular growth patterns. Salivary gland like tumors of the breast show a great variety of architectural patterns and cellular differentiations such as glandular, myoepithelial, squamous, and even mesenchymal phenotypes. Myoepithelioma of minor salivary glands a diagnostic challenge. Myoepithelial carcinoma malignant myoepithelioma of the parotid. Composed of a mixed population of spindled, epithelioid, and plasmacytoid cells arranged around a. Links to pubmed are also available for selected references.
It can be present in individuals of a wide age range including children and adults the cause of formation of salivary gland myoepithelioma is not wellunderstood, although certain chromosomal alterations and gene mutations have been. Myoepithelioma is a rare benign myoepithelial tumour and its malignant counterpart is myoepithelial carcinoma. The tumors mostly present as asymptomatic, slowly progressive masses over a period of months to years in the patient with average age in the fourth decade 1. Salivary gland cytology and the milan system for reporting. Abstract myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral cavity. Summarythe present paper describes the clinical and pathologic features of a benign myoepithelioma of the p arotid gland.
Mar 18, 2015 myoepithelioma was recognized as a histologically distinct entity by the world health organization who in 1991. Myoepithelioma is a rare but wellcharacterized group of tumours, among which myoepithelioma of the salivary glands is the best known. Myoepithelioma of salivary glands american cancer society journals. This tumour may be particularly locally aggressive, but its clinical and biological features are not yet fully understood. Myoepithelial carcinoma can arise in both minor and major salivary glands but with a predilection for the parotid gland. Diagnosis of myoepithelioma through light microscopy is possible and immunohistochemistry is done to facilitate the diagnosis. Pure accounting for less than 1% of all salivary gland tumors. The most common site is parotid gland with a few arising in minor salivary glands of the oral cavity and palate. The tumor is composed exclusively of myoepithelial cells that show spindle, plasmacytoid, and clear cell morphology. Although they are an important element in many salivary gland tumors, 1 pure myoepitheliomas are rare, accounting for of all salivary gland tumors. A case of dedifferentiated malignant myoepithelioma in a 59.
An 8yearsold female patient visited our clinic with a chief complaint of a painless swelling on the palate. Myoepitheliomas mes are rare tumors of the parotid gland. The histological types of primitive salivary gland type tumors arising in the lung are very infrequent. The treatment of myoepitheliomas is complete removal of the tumor. Since 1943 when sheldon identified them and characterized them as myoepithelioma, less than 100 cases have been reported in the literature. Get a printable copy pdf file of the complete article 2. Rare primary lesions that have been known to metastasize to the skin include an adenoid cystic carcinoma, an acinic cell carcinoma, a myoepithelial carcinoma, and adenocarcinoma of the salivary gland, 365370 an adenoid cystic carcinoma of the lacrimal gland, 371 an ameloblastoma, 372 a thymoma, 373 an adrenal carcinoma, 374,375 a pheochromocytoma, 376 and carcinomas of the hypopharynx, 377 nasopharynx, 31,378,379 and larynx. A similar tumor type may be found in the tongue, referred to as ectomesenchymal chondromyxoid tumor. Hamperl defined tumors containing mainly myoepithelial cells that are composed of three morphologic types. Conservative treatment that preserves the overlaying palatal mucosa while surgically excising the tumor was carried out under general anesthesia, because the. Plasmacytoid myoepithelioma of minor salivary glands. Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral cavity. Rather, we believe that in general, physicians are simply unaware of its existence.
Myoepitheliomas are rare benign neoplasias of the salivary gland, more commonly found in the parotid 1,2, being responsible for less than 7% of salivary gland tumors. Jul 11, 2008 myoepithelioma is a rare benign neoplasm. The diagnosis is rendered histopathologically, and it includes the. Collagenizedstroma, chondroidor chondromyxoidareas looks like pa but without ductal cells. Normal salivary gland cytology non diagnosticcontinued e. These tumors can occur in most of the glandular structures like salivary glands, breast and sweat glands of the skin. Dedifferentiated salivary gland tumor is a rare, recently recognized tumor type. Although they are an important element in many salivary gland tumors, 1 pure myoepitheliomas are rare, accounting for salivary gland tumors. Histological examination of the second recurrence showed a malignant spindle cell neoplasm with. It is normally located in the major salivary glands. Classically, they are found in the parotid gland or palate. They present as bulky, bosselated, slowgrowing tumors that maybecomelarge. Malignant myoepithelioma of the parotid gland crissman.
Myoepitheliomas of minor salivary glands accounts to only 1. Benign salivary gland tumors were seen in 38 cases. Myoepithelioma of minor salivary glands a diagnostic. Pdf myoepithelioma of minor salivary gland on the base. Mar 27, 2018 myoepithelioma of salivary gland is an uncommon benign tumor typically arising in the major salivary glands. The recurrence rate is similar to that of the pleomorphic adenoma 1518%.
They are seen as reddishyellow masses, which may be solid or a mixture of solid and cystic. Subsequently, it was designated variously as the parotid clear cell adenoma probably of myoepithelial derivation or adenomyopeithelioma. Myoepitheliomas are most common in young adults between the ages of 30 and 50 and there are very few cases reported in. Previously reported cases have been either benign or, at most, locally aggressive. Aug 26, 2009 myoepithelioma is a rare salivary gland tumor arising from proliferation of myoepithelial cells. Case selection was from the files of the armed forces.
Mc usually presents as a slowgrowing painless mass arising in the parotid gland, but may involve other salivary glands. Two cases of myoepithelioma occurring in the parotid gland were reported. Pdf minimally invasive surgery in a pediatric palatal. Myoepithelial carcinoma malignant myoepithelioma of the. These tumors consisted of spindle cells that exhibited an arrangement similar to leiomyoma or fibroma. Myoepithelioma of salivary glands are very rare, accounting for only 1%1. Presentation may be the same as other benign salivary gland tumors.
Fewer than 100 cases had been reported through 1993. Pdf myoepithelioma of a minor salivary gland of the. Histopathologically, the tumor was composed of epithelioid cells with eosinophilic cytoplasm and eccentric nuclei arranged in cords and files. Epithelialmyoepithelial carcinoma of the parotid gland. Myoepithelioma is a rare and usually benign salivary gland tumor derived from myoepithelial cells. These may be positive for alpha smooth muscle actin and can contract and expel the secretions of exocrine glands. Myoepithelioma, salivary glands, mouse springerlink. The sections show a stratified squamous epithelium with a thin layer of parakeratosis, minor salivary glands, and a wellcircumscribed cystic lesion. Voluminous myoepithelioma of the minor salivary glands. Myoepithelioma of minor salivary gland on the base of the tongue. Many tumors are heterogeneous, containing an admixture of epithelioid and spindled cells, reticular areas merging with solid figure 1. Myoepithelioma of the salivary gland was formally categorized as a salivary neoplasm in 1991 2,3.
The proportion of parotid myoepitheliomas range from. Myoepithelioma is a rare disease in the salivary gland. Pdf myoepithelioma is a benign salivary gland tumor in the head and neck region, accounting for 11. Analysis of the clinical relevance of histological classification of. Also precursor benign lesions were seen only in 24% of cases n 12. Myoepithelial tumors of the salivary gland including myoepitheliomas benign and myoepithelial carcinomas malignant are a rare group of. Myoepithelioma of the lung european journal of cardio. Capsules are generally better developed in tumors of the major glands, whereas those arising in the palate or other minor salivary or seromucinous gland sites are circumscribed but not usually encapsulated. While myoepithelioma has no specific clinical features, it is accepted pathologically as a distinct entity. They are encapsulated or at least wellcircumscribed tumours and the majority arise in the parotid gland.
It can be present in individuals of a wide age range including children and adults. Only a few case reports describing ct imaging features of me have been published. Losito nsbotti gionna fpasquinelli gminenna pbisceglia m clearcell myoepithelial carcinoma of the salivary glands. Immunohistochemistry is a useful tool for diagnosing salivary gland and head and neck tumors. Myoepithelioma is a wellcircumscribed or encapsulated tumor. Nov 18, 2016 yes, in addition to occurring in the salivary glands, this type of cancer can also occur in the skin or soft tissues. Subsequently the tumour recurred twice and was characterised by invasion of the mandible. In this report, we describe two cases of a benign myoepithelioma of the p arotid gland.
Table 1 2017 who classification of benign epithelial salivary gland tumours. A myoepithelial carcinoma, a rare malignant salivary gland neoplasm, arose in a pleomorphic adenoma of the parotid gland. Sheldon initially published his work on a myoepithelioma in 1943, and first in 1991 and later in 2005 myoepithelioma was recognized from the who as a distinct entity 2, 3. Benign myoepithelialtumor, 2% of salivary gland neoplasms, 6% of minor salivary gland tumors 3rd5thdecade, m. Myoepithelioma of the head and neck, also myoepithelioma, is a salivary gland tumour of the head and neck that is usually benign as the name suggests, it consists of myoepithelial cells. Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary glands of the oral cavity.
Tanahashi j, kashima k, daa t, kondo y, kuratomi e, yokoyama s. They commonly occur in salivary glands, but they have also been reported in the nasopharynx, larynx, breast and lung 1, 2. Malignant salivary gland tumors were seen in 16 cases. Such lesion shows a varied pattern of morphological growth, it may be solid, myxoid or reticular. Health, general cancer diagnosis research cancer diagnosis carcinoembryonic antigen genetic aspects cea oncology immunohistochemistry intermediate filament proteins medical research medicine, experimental salivary gland tumors tumor proteins. They are found in the sweat glands, mammary glands, lacrimal glands, and salivary glands. Myoepithelial carcinoma an overview sciencedirect topics. Myoepithelioma is usually a benign tumor arising from neoplastic myoepithelial or. Myoepithelioma is more common in adults than in children or adolescents.
Myoepithelioma of the parotid gland with extensive. Myoepithelioma of salivary gland is an uncommon benign tumor typically arising in the major salivary glands. Myoepithelioma of parotid gland presenting as infraauricular. The histopathology shows several architectural patterns such as trabecular, glandular, partly cystic, and solid. The diagnosis was made on the basis of characteristic ultrastructural as well as immunohistochemical findings. The criteria to differentiate between pa and myoepithelioma i. Salivary gland malignant myoepithelioma nagao 1998. This included 6 cases of mucoepidermoid carcinoma, 3. Pdf myoepithelioma, a benign tumor, occurs with a frequency of 1. Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral. Original research myoepithelioma of the p arotid gland. Despite wide distribution of myoepithelial cells in the bronchial mucous glands, few tumors of myoepithelial origin have been reported in the lung.
Dedifferentiated malignant myoepithelioma of the parotid gland. Salivary duct stone with cystaspiration yields clear fluid, no more massthen adequate as it explains the scenario bilateral enlarged salivary glands with no definite mass, then adequate however, if mass, and all you get is normal salivary gland tissue. Salivary gland myoepithelioma with focal capsular invasion. Abstractmalignant myoepithelioma of salivary gland which is also known as myoepithelial carcinoma is a rare disease. Only three cases of sinonasal myoepithelioma have been reported in the literature. In this report, we describe two cases of a benign myoepithelioma of the parotid gland. It was once considered to be a type of pleomorphic adenoma pa, but myoepitheliomas are today believed to be relatively aggressive tumors. Approximately 66% of these tumors occur in a part of the salivary gland, known as the parotid gland. They are essentially represented by the mucoepidermoid carcinoma, the adenoid cystic carcinoma and the pleomorphic adenoma. The cystic lesion has a mildly fibrotic appearing wall, is lined by histiocytes intermixed with rare lymphocytes, and contains mucous and macrophages.
Through 1985, only 42 other cases had been reported in the literature. Only 1% of all salivary gland neoplasms are myoepitheliomas. Myoepithelioma me is a benign salivary gland tumor composed almost exclusively of sheets, islands, or cords of cells with myoepitheliomal differentiation. We present here a case of a malignant myoepithelioma of the parotid gland, confirmed by electron microscopy, that was locally aggressive and eventually metastasized. Myoepithelioma occurring in minor salivary glands of oral cavity accounts for 26% of all salivary gland myoepitheliomas and palate being the most common site 69. We describe a myoepithelioma of cervical soft tissue. Benign myoepithelioma is extremely rare in the lung, to the best of our knowledge. To evaluate cellular composition of salivary gland adenomas using 3 monoclonal antibodies that recognize a smooth muscle phenotype confirmed to be sensitive for myoepithelial differentiation.
Fine needle aspiration cytology of salivary gland lesions. We have located a case report of cutaneous myoepithelial carcinoma occurring on a persons back. Jan, 2005 myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral cavity. Myoepitheliomas are exceedingly rare cutaneous tumors that present as domeshaped, exophytic nodules on the face, neck, extremities, or trunk. Myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. Full text full text is available as a scanned copy of the original print version. Myoepithelial carcinoma malignant myoepithelioma of the parotid gland arising in a pleomorphic adenoma. Malignant myoepithelioma of the salivary gland is discussed in. The benign salivary corpuscular bassinetmyoepithelioma. The tumor cells of the two cases likewise contained myofilaments and gave a positive result for the s.
It is a benign salivary gland tumor that consists entirely of myoepithelial cells with variable cellular morphologies including spindle, epithelioid, plasmacytoid, or clear cells. Malignant myoepithelioma mme of the salivary gland, also known as. A myoepithelial carcinoma, a rare malignant salivary gland neoplasm, arose in a. Review and updates of immunohistochemistry in selected salivary gland and head and neck tumors shaobo zhu, md. Tani, lambert skoog, in comprehensive cytopathology third edition, 2008. Salivary gland malignant myoepithelioma nagao 1998 cancer. Soft tissue myoepithelial me carcinoma, also known as soft tissue malignant myoepithelioma stmm, and myoepithelioma are rare entities, part of me tumors.
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